Radioprotective agents pdf
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In vitro radioprotective effects of histamine H2 receptor antagonist against gamma-rays induced chromosomal aberrations in human lymphocytes.
Background: Radioprotective capability of histamine H2 receptor antagonists have been shown in several in vivo studies mainly using animal models. However, to verify the effectiveness of these agents in clinical applications, studies should be performed on human cells. In the present study radioprotective properties of these agents was examined in vitro on human lymphocytes using metaphase anal...
متن کاملThe effect of some radioprotective substances on the redox equilibrium in the spleen.
The redox potential of spleen tissue in aiao was measured, and changes were observed after the administration of radioprotective drugs with reducing properties (aminothiols, dimercaptans, hydrazine derivatives, glucose, sulphites). The redox potential can be regarded as an indicator of the level of the energy metabolism of a tissue. The depression of the energy metabolism could be correlated wi...
متن کاملفراورده های طبیعی با قابلیت محافظت پرتوی
Since exposure to irradiation in radiotherapy or unwanted radiation, induces side effects to health, it is important to makear effort to protect humans against side effects induced by irradiation. In these cases, radioprotective drugs could be used to reduce or delay the side effects and the mortality induced by irradiation. Although, thiol compounds were early compounds in these categories, ...
متن کاملDevelopment of Antioxidant COX-2 Inhibitors as Radioprotective Agents for Radiation Therapy—A Hypothesis-Driven Review
Radiation therapy (RT) evolved to be a primary treatment modality for cancer patients. Unfortunately, the cure or relief of symptoms is still accompanied by radiation-induced side effects with severe acute and late pathophysiological consequences. Inhibitors of cyclooxygenase-2 (COX-2) are potentially useful in this regard because radioprotection of normal tissue and/or radiosensitizing effects...
متن کاملSuccinate ester derivative of δ-tocopherol enhances the protective effects against 60Co γ-ray-induced hematopoietic injury through granulocyte colony-stimulating factor induction in mice
α-tocopherol succinate (α-TOS), γ-tocotrienol (GT3) and δ-tocotrienol (DT3) have drawn large attention due to their efficacy as radioprotective agents. α-TOS has been shown to act superior to α-tocopherol (α-TOH) in mice by reducing lethality following total body irradiation (TBI). Because α-TOS has been shown to act superior to α-tocopherol (α-TOH) in mice by reducing lethality following total...
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